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Cost is supported by the EU Framework Programme Horizon 2020
 
7/13/2015 (Added to site)
Author(s): Christo Nanev and Vesselin Tonchev

Sigmoid kineticsofproteincrystalnucleation

Journal: Journal of Crystal Growth
DOI: http://dx.doi.org/10.1016/j.jcrysgro.2015.07.007
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 A non-linear differential equation expressing the new phase nucleation rate in the different steps of the process (non-stationary and stationary nucleation and in the plateau region) is derived from basic principles of the nucleation theory.It is shown that one and the same sigmoid (logistic)function describes both nucleation scenarios:the one according to the classical theory, and the other according to the modern two-stage mechanism of protein crystal formation.Comparison to experimental data on both insulin crystal nucleation kinetics and on bovine β-lactoglobulin crystallization indicates a good agreement with the sigmoidal prediction.Experimental data for electrochemical nucleation and glass crystallization obey the same sigmoid time dependence, and suggest universality of this nucleation kinetics law.



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